Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Diazoxide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Diazoxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides and oral diazoxide both raise blood glucose, so combined use can worsen hyperglycemia. Additive hypotension and hyperuricemia may also occur.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diazoxide belongs to Miscellaneous.
Why it happens
Additive hyperglycemic effects: diazoxide inhibits insulin release and thiazides impair glucose tolerance.
What to do
Monitor blood glucose and blood pressure, and adjust diazoxide dose or antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Diazoxide
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Diazoxide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Diazoxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides and oral diazoxide both raise blood glucose, so combined use can worsen hyperglycemia. Additive hypotension and hyperuricemia may also occur.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diazoxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and blood pressure, and adjust diazoxide dose or antidiabetic therapy as required.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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