Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Eltrombopag
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 in vitro, which could in theory raise valsartan exposure, although the legacy note describes a decrease, which is inconsistent. A clinically meaningful change in valsartan effect has not been established.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Eltrombopag belongs to Miscellaneous.
Why it happens
Possible OATP1B1 inhibition by eltrombopag affecting valsartan hepatic uptake; not clinically established.
What to do
No dose adjustment is needed; monitor blood pressure if the clinical response changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Eltrombopag?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits OATP1B1 in vitro, which could in theory raise valsartan exposure, although the legacy note describes a decrease, which is inconsistent. A clinically meaningful change in valsartan effect has not been established.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure if the clinical response changes.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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