Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Etodolac
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as etodolac blunt the antihypertensive effect of valsartan and hydrochlorothiazide through sodium and water retention. In combination with an ARB and a diuretic, NSAIDs can also cause acute kidney injury, particularly in older or volume-depleted patients, and may raise potassium.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and promotes sodium retention, opposing antihypertensive effects and impairing glomerular filtration when angiotensin II action is blocked.
What to do
Use the lowest effective NSAID dose for the shortest time, maintain hydration, and monitor blood pressure, creatinine and potassium. Consider paracetamol or another alternative if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Etodolac?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as etodolac blunt the antihypertensive effect of valsartan and hydrochlorothiazide through sodium and water retention. In combination with an ARB and a diuretic, NSAIDs can also cause acute kidney injury, particularly in older or volume-depleted patients, and may raise potassium.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, maintain hydration, and monitor blood pressure, creatinine and potassium. Consider paracetamol or another alternative if appropriate.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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