Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Felodipine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felodipine and amlodipine are both dihydropyridine calcium channel blockers, so using them together duplicates therapy. This increases the risk of hypotension, peripheral oedema, flushing and headache without a clear additional benefit.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Felodipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade produces additive vasodilation.
What to do
Avoid combining two dihydropyridines and keep a single agent. If both have been taken, check blood pressure and look for oedema, then stop one.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Felodipine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Felodipine and amlodipine are both dihydropyridine calcium channel blockers, so using them together duplicates therapy. This increases the risk of hypotension, peripheral oedema, flushing and headache without a clear additional benefit.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two dihydropyridines and keep a single agent. If both have been taken, check blood pressure and look for oedema, then stop one.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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