Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Folic acid
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Folic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may slightly increase urinary loss of folate. A clinically meaningful deficiency is unlikely in patients with adequate diet.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Folic acid belongs to Miscellaneous.
Why it happens
Thiazide-related increase in renal folate clearance.
What to do
No routine action is needed; consider checking folate status only in patients with poor intake, malabsorption or other risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Folic acid
- Ethotoin + Folic acid Moderate
- Folic acid + Fosphenytoin Moderate
- Folic acid + Glucarpidase Moderate
- Folic acid + Methotrexate Moderate
- Folic acid + Pafolacianine Moderate
- Folic acid + Phenobarbital Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Folic acid?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Folic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics may slightly increase urinary loss of folate. A clinically meaningful deficiency is unlikely in patients with adequate diet.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Folic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; consider checking folate status only in patients with poor intake, malabsorption or other risk factors.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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