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Drug interactions

Amlodipine-hydrochlorothiazide-valsartan + Ketoprofen

Severity: Major

Amlodipine-hydrochlorothiazide-valsartan and Ketoprofen: major interaction.

Last updated Sources: US FDA label

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

NSAIDs such as ketoprofen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. With an ARB and a diuretic, NSAID use raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may cause hyperkalemia.

What this interaction means in plain words

Amlodipine-hydrochlorothiazide-valsartan and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.

Evidence level: High

Why it happens

NSAIDs inhibit renal prostaglandin synthesis, causing sodium retention and reduced glomerular perfusion that is dependent on angiotensin blockade.

What to do

Avoid regular NSAID use where possible, or use the lowest dose for the shortest time with adequate hydration. Monitor blood pressure, serum creatinine, and potassium.

What to ask your pharmacist

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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References

Frequently asked questions

Can I take Amlodipine-hydrochlorothiazide-valsartan with Ketoprofen?

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Ketoprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as ketoprofen can blunt the antihypertensive effect of valsartan and hydrochlorothiazide. With an ARB and a diuretic, NSAID use raises the risk of acute kidney injury, especially in elderly or volume-depleted patients, and may cause hyperkalemia.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Ketoprofen?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible, or use the lowest dose for the shortest time with adequate hydration. Monitor blood pressure, serum creatinine, and potassium.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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