Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Lemborexant
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may increase lemborexant exposure, increasing next-day somnolence and impairment. Labeling advises limiting the lemborexant dose with weak CYP3A inhibitors.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by amlodipine decreases lemborexant clearance.
What to do
Limit lemborexant to the lower dose recommended in labeling for weak CYP3A inhibitors. Counsel about next-day drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lemborexant?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may increase lemborexant exposure, increasing next-day somnolence and impairment. Labeling advises limiting the lemborexant dose with weak CYP3A inhibitors.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the lower dose recommended in labeling for weak CYP3A inhibitors. Counsel about next-day drowsiness and driving.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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