Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Levodopa
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can add to the blood-pressure-lowering effect of antihypertensives, causing orthostatic hypotension, dizziness or falls. The effect is most notable when levodopa is started or its dose is raised.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Dopamine formed from levodopa produces vasodilation and reduced sympathetic tone, adding to the pharmacodynamic effects of the antihypertensive agents.
What to do
Monitor supine and standing blood pressure when starting or titrating levodopa. Lower the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Levodopa?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can add to the blood-pressure-lowering effect of antihypertensives, causing orthostatic hypotension, dizziness or falls. The effect is most notable when levodopa is started or its dose is raised.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure when starting or titrating levodopa. Lower the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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