Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Mifepristone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise amlodipine concentrations, increasing the risk of hypotension, flushing and peripheral edema. Higher exposure is most relevant with prolonged high-dose use, such as in Cushing syndrome. Effects on valsartan are theoretical.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing amlodipine clearance.
What to do
Monitor blood pressure and edema during prolonged mifepristone therapy and reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Mifepristone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise amlodipine concentrations, increasing the risk of hypotension, flushing and peripheral edema. Higher exposure is most relevant with prolonged high-dose use, such as in Cushing syndrome. Effects on valsartan are theoretical.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema during prolonged mifepristone therapy and reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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