Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nadolol
Severity: Minor
Amlodipine-hydrochlorothiazide-valsartan and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nadolol adds to the blood pressure lowering of the triple combination and may cause bradycardia or hypotension. Thiazides can modestly worsen glucose and lipid effects of beta-blockers. Potassium effects are minor.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects.
What to do
Monitor blood pressure and heart rate after starting or changing doses. Adjust doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nadolol?
MediHelp rates the interaction as minor. Amlodipine-hydrochlorothiazide-valsartan and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nadolol adds to the blood pressure lowering of the triple combination and may cause bradycardia or hypotension. Thiazides can modestly worsen glucose and lipid effects of beta-blockers. Potassium effects are minor.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after starting or changing doses. Adjust doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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