Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Nicardipine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy. This increases the risk of hypotension, edema, flushing and reflex tachycardia without added benefit. Nicardipine also weakly inhibits CYP3A4.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Therapeutic duplication of L-type calcium channel blockade, with possible minor CYP3A4 inhibition raising amlodipine levels.
What to do
Avoid concurrent use of two dihydropyridines; choose one agent. If transition is needed, monitor blood pressure closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Nicardipine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a dihydropyridine calcium channel blocker, so combining it with amlodipine duplicates therapy. This increases the risk of hypotension, edema, flushing and reflex tachycardia without added benefit. Nicardipine also weakly inhibits CYP3A4.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two dihydropyridines; choose one agent. If transition is needed, monitor blood pressure closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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