Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Prednisone
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone and the thiazide component both promote renal potassium loss, so used together they can lower serum potassium more than either alone. Hypokalemia can cause weakness and arrhythmias, particularly in patients on digoxin or with heart disease.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Prednisone belongs to Endocrine.
Why it happens
Additive kaliuretic effects: thiazide-induced distal potassium wasting plus mineralocorticoid activity of prednisone.
What to do
Check serum potassium and magnesium at baseline and periodically during prolonged or high-dose prednisone use. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Prednisone?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prednisone and the thiazide component both promote renal potassium loss, so used together they can lower serum potassium more than either alone. Hypokalemia can cause weakness and arrhythmias, particularly in patients on digoxin or with heart disease.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically during prolonged or high-dose prednisone use. Replace potassium as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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