Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Probenecid
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may raise serum uric acid and reduce the uricosuric effect of probenecid. Thiazides compete for renal tubular anion transport, which may alter drug handling, so gout control may be less effective.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Thiazide-induced uric acid retention and competition for renal organic anion secretion antagonize probenecid's uricosuric action.
What to do
Monitor serum uric acid and gout symptoms; adjust the probenecid dose or consider an alternative antihypertensive if control is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Probenecid?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide may raise serum uric acid and reduce the uricosuric effect of probenecid. Thiazides compete for renal tubular anion transport, which may alter drug handling, so gout control may be less effective.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout symptoms; adjust the probenecid dose or consider an alternative antihypertensive if control is poor.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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