Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Quinidine
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a basic drug that is secreted by renal tubular cation transport and may compete with hydrochlorothiazide for tubular secretion. This could modestly raise hydrochlorothiazide exposure, although the clinical effect is generally small. Thiazide-induced hypokalemia or hypomagnesemia also raises the risk of quinidine-related QT prolongation.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular secretion of hydrochlorothiazide, plus thiazide-induced electrolyte disturbances that augment quinidine proarrhythmic effects.
What to do
Monitor serum potassium and magnesium and correct deficiencies. Obtain an ECG if QT-related symptoms or other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Quinidine?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a basic drug that is secreted by renal tubular cation transport and may compete with hydrochlorothiazide for tubular secretion. This could modestly raise hydrochlorothiazide exposure, although the clinical effect is generally small. Thiazide-induced hypokalemia or hypomagnesemia also raises the risk of quinidine-related QT prolongation.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficiencies. Obtain an ECG if QT-related symptoms or other QT-prolonging drugs are present.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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