Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Secobarbital
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital can induce CYP3A4 and lower amlodipine concentrations, possibly reducing blood pressure control. Additive sedation and hypotension may also occur.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of hepatic and intestinal CYP3A4 increases amlodipine clearance.
What to do
Monitor blood pressure when secobarbital is started or stopped. Increase the amlodipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Secobarbital?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital can induce CYP3A4 and lower amlodipine concentrations, possibly reducing blood pressure control. Additive sedation and hypotension may also occur.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when secobarbital is started or stopped. Increase the amlodipine dose if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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