Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Verapamil
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and may raise amlodipine exposure, and it also lowers blood pressure and slows AV conduction. Combining with amlodipine, a second calcium channel blocker, leads to additive hypotension and edema.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive calcium channel blockade and verapamil inhibition of CYP3A4 metabolism of amlodipine.
What to do
Avoid routine combination of two calcium channel blockers where possible. If used together, monitor blood pressure, heart rate and edema and reduce the amlodipine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Verapamil?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and may raise amlodipine exposure, and it also lowers blood pressure and slows AV conduction. Combining with amlodipine, a second calcium channel blocker, leads to additive hypotension and edema.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination of two calcium channel blockers where possible. If used together, monitor blood pressure, heart rate and edema and reduce the amlodipine dose as needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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