Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Voclosporin
Severity: Major
Amlodipine-hydrochlorothiazide-valsartan and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin is a calcineurin inhibitor that is nephrotoxic and can cause hyperkalemia. With an ARB, the risk of hyperkalemia and reduced glomerular filtration increases. Hypovolemia from the diuretic may add to renal risk.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive hyperkalemia and renal hemodynamic impairment from calcineurin inhibition and RAAS blockade.
What to do
Monitor eGFR and serum potassium closely, particularly after starting or changing doses, and reduce or hold voclosporin per labeling if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Voclosporin?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin is a calcineurin inhibitor that is nephrotoxic and can cause hyperkalemia. With an ARB, the risk of hyperkalemia and reduced glomerular filtration increases. Hypovolemia from the diuretic may add to renal risk.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium closely, particularly after starting or changing doses, and reduce or hold voclosporin per labeling if renal function declines.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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