Drug interactions
Amlodipine-olmesartan + Aprepitant
Severity: Minor
Amlodipine-olmesartan and Aprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor, particularly with multi-day use, and may raise amlodipine exposure. This could cause more hypotension or peripheral edema, though the effect is usually modest.
What this interaction means in plain words
Amlodipine-olmesartan and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Aprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant inhibits CYP3A4, reducing amlodipine metabolism.
What to do
Monitor blood pressure and for edema or dizziness during aprepitant courses; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Aprepitant?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Aprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aprepitant is a moderate CYP3A4 inhibitor, particularly with multi-day use, and may raise amlodipine exposure. This could cause more hypotension or peripheral edema, though the effect is usually modest.
How serious is the interaction between Amlodipine-olmesartan and Aprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or dizziness during aprepitant courses; no routine dose change is needed.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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