Drug interactions
Amlodipine-olmesartan + Bumetanide
Severity: Moderate
Amlodipine-olmesartan and Bumetanide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics add to the blood pressure lowering effect of olmesartan, and in volume-depleted patients can cause marked hypotension and renal impairment. Their potassium-losing effect usually offsets the potassium-raising effect of the ARB.
What this interaction means in plain words
Amlodipine-olmesartan and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Bumetanide belongs to Cardiovascular.
Why it happens
Additive hypotension and volume depletion with renin-angiotensin blockade, with opposing effects on potassium handling.
What to do
Monitor blood pressure, renal function and electrolytes, particularly when starting or increasing the diuretic. Consider reducing the diuretic dose if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Bumetanide
Frequently asked questions
Can I take Amlodipine-olmesartan with Bumetanide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Bumetanide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics add to the blood pressure lowering effect of olmesartan, and in volume-depleted patients can cause marked hypotension and renal impairment. Their potassium-losing effect usually offsets the potassium-raising effect of the ARB.
How serious is the interaction between Amlodipine-olmesartan and Bumetanide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, particularly when starting or increasing the diuretic. Consider reducing the diuretic dose if volume depletion occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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