Drug interactions
Amlodipine-olmesartan + Canagliflozin
Severity: Moderate
Amlodipine-olmesartan and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin can cause volume depletion and hypotension, and with olmesartan may increase the risk of acute kidney injury. Canagliflozin has been associated with small rises in potassium, mainly in renally impaired patients taking RAAS inhibitors.
What this interaction means in plain words
Amlodipine-olmesartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
Additive effects of osmotic diuresis and renin-angiotensin blockade on volume status and renal hemodynamics.
What to do
Assess volume status and renal function before starting canagliflozin and monitor creatinine, potassium and blood pressure afterward. Reduce antihypertensive or diuretic doses if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Amlodipine-olmesartan with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin can cause volume depletion and hypotension, and with olmesartan may increase the risk of acute kidney injury. Canagliflozin has been associated with small rises in potassium, mainly in renally impaired patients taking RAAS inhibitors.
How serious is the interaction between Amlodipine-olmesartan and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before starting canagliflozin and monitor creatinine, potassium and blood pressure afterward. Reduce antihypertensive or diuretic doses if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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