Drug interactions
Amlodipine-perindopril + Canagliflozin
Severity: Moderate
Amlodipine-perindopril and Canagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin is generally not strongly hyperkalemic, but it can cause volume depletion and hypotension, and combined with an ACE inhibitor may impair kidney function. Canagliflozin has been associated with small potassium rises in patients with renal impairment.
What this interaction means in plain words
Amlodipine-perindopril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Canagliflozin belongs to Endocrine.
Why it happens
Additive effects: osmotic diuresis and volume contraction with ACE inhibitor reduction of efferent arteriolar tone may lower glomerular filtration and impair potassium excretion.
What to do
Check volume status, blood pressure, renal function and serum potassium after starting canagliflozin; reduce diuretic doses if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Amlodipine-perindopril with Canagliflozin?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Canagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin is generally not strongly hyperkalemic, but it can cause volume depletion and hypotension, and combined with an ACE inhibitor may impair kidney function. Canagliflozin has been associated with small potassium rises in patients with renal impairment.
How serious is the interaction between Amlodipine-perindopril and Canagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check volume status, blood pressure, renal function and serum potassium after starting canagliflozin; reduce diuretic doses if the patient is volume depleted.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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