Drug interactions
Amlodipine-olmesartan + Colesevelam
Severity: Moderate
Amlodipine-olmesartan and Colesevelam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam binds olmesartan in the gut and reduces its absorption, which may weaken blood pressure control. The effect is greatest when both are taken at the same time.
What this interaction means in plain words
Amlodipine-olmesartan and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Colesevelam belongs to Endocrine.
Why it happens
Bile acid sequestrant binding of olmesartan in the gastrointestinal tract reduces its absorption.
What to do
Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if dosing times cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
- Colesevelam + Gliclazide Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan with Colesevelam?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam binds olmesartan in the gut and reduces its absorption, which may weaken blood pressure control. The effect is greatest when both are taken at the same time.
How serious is the interaction between Amlodipine-olmesartan and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if dosing times cannot be separated.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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