Drug interactions
Chenodiol + Colesevelam
Severity: Moderate
Chenodiol and Colesevelam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bile acid sequestrants can bind chenodiol in the gut and reduce its absorption, and they also oppose its effect on bile acid pool. This may reduce gallstone dissolution or therapeutic effect.
What this interaction means in plain words
Chenodiol and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodiol belongs to Gastrointestinal Tract; Colesevelam belongs to Endocrine.
Why it happens
Resin binding of bile acids in the gut lowers absorption and enterohepatic availability of chenodiol.
What to do
Avoid concurrent use if possible; if needed, separate doses by several hours and monitor treatment response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
- Colesevelam + Gliclazide Moderate
Other interactions of Chenodiol
- Aluminum hydroxide + Chenodiol Moderate
- Calcium carbonate + Chenodiol Moderate
- Calcium + Chenodiol Moderate
- Chenodiol + Cholestyramine Moderate
- Chenodiol + Colestipol Moderate
- Chenodiol + Warfarin Moderate
Frequently asked questions
Can I take Chenodiol with Colesevelam?
MediHelp rates the interaction as moderate. Chenodiol and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can bind chenodiol in the gut and reduce its absorption, and they also oppose its effect on bile acid pool. This may reduce gallstone dissolution or therapeutic effect.
How serious is the interaction between Chenodiol and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; if needed, separate doses by several hours and monitor treatment response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Cholic acid. The full list is on the Colesevelam page.
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