Drug interactions
Colesevelam + Gliclazide
Severity: Moderate
Colesevelam and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may bind sulfonylureas in the gut and reduce absorption, which can weaken glycemic control. This has been shown with glipizide-type agents and is likely a class effect.
What this interaction means in plain words
Colesevelam and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Bile acid sequestrant binds the sulfonylurea in the gastrointestinal tract, reducing absorption.
What to do
Give gliclazide at least four hours before colesevelam. Monitor glucose if the dosing schedule changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Cyclosporine Moderate
Frequently asked questions
Can I take Colesevelam with Gliclazide?
MediHelp rates the interaction as moderate. Colesevelam and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam may bind sulfonylureas in the gut and reduce absorption, which can weaken glycemic control. This has been shown with glipizide-type agents and is likely a class effect.
How serious is the interaction between Colesevelam and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gliclazide at least four hours before colesevelam. Monitor glucose if the dosing schedule changes.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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