Drug interactions
Amlodipine-olmesartan + Digoxin
Severity: Minor
Amlodipine-olmesartan and Digoxin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy premise that digoxin raises serum potassium is not accurate; digoxin toxicity actually causes hyperkalemia only in overdose. However, olmesartan can cause hyperkalemia or renal impairment, and electrolyte shifts and reduced renal function alter digoxin handling and toxicity risk. Clinically the combination is commonly used and is usually manageable.
What this interaction means in plain words
Amlodipine-olmesartan and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
Why it happens
ARB-related changes in potassium and renal function may indirectly alter digoxin sensitivity and clearance; no direct pharmacokinetic interaction is established.
What to do
Monitor serum potassium, renal function and digoxin concentration if clinical signs of toxicity appear or renal function changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Digoxin?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Digoxin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy premise that digoxin raises serum potassium is not accurate; digoxin toxicity actually causes hyperkalemia only in overdose. However, olmesartan can cause hyperkalemia or renal impairment, and electrolyte shifts and reduced renal function alter digoxin handling and toxicity risk. Clinically the combination is commonly used and is usually manageable.
How serious is the interaction between Amlodipine-olmesartan and Digoxin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and digoxin concentration if clinical signs of toxicity appear or renal function changes.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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