Drug interactions
Amlodipine-olmesartan + Fedratinib
Severity: Moderate
Amlodipine-olmesartan and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can raise amlodipine exposure. This may cause more hypotension, dizziness and peripheral edema.
What this interaction means in plain words
Amlodipine-olmesartan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated amlodipine metabolism by fedratinib reduces its clearance.
What to do
Monitor blood pressure and edema when fedratinib is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Fedratinib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can raise amlodipine exposure. This may cause more hypotension, dizziness and peripheral edema.
How serious is the interaction between Amlodipine-olmesartan and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when fedratinib is started or stopped. Reduce the amlodipine dose if hypotension or adverse effects occur.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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