Drug interactions
Chloramphenicol + Fedratinib
Severity: Major
Chloramphenicol and Fedratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4 and to a lesser extent by CYP2C19, and its levels rise with enzyme inhibition. Higher exposure may increase gastrointestinal toxicity, myelosuppression and the risk of encephalopathy including Wernicke's.
What this interaction means in plain words
Chloramphenicol and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Fedratinib belongs to Oncology.
Why it happens
Chloramphenicol inhibits CYP3A4 and CYP2C19, reducing fedratinib metabolism.
What to do
Avoid if possible. If necessary, reduce the fedratinib dose per labeling for strong CYP3A4 inhibitors and monitor blood counts, thiamine status and neurologic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Cimetidine + Fedratinib Major
Frequently asked questions
Can I take Chloramphenicol with Fedratinib?
MediHelp rates the interaction as major. Chloramphenicol and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is metabolized by CYP3A4 and to a lesser extent by CYP2C19, and its levels rise with enzyme inhibition. Higher exposure may increase gastrointestinal toxicity, myelosuppression and the risk of encephalopathy including Wernicke's.
How serious is the interaction between Chloramphenicol and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If necessary, reduce the fedratinib dose per labeling for strong CYP3A4 inhibitors and monitor blood counts, thiamine status and neurologic symptoms.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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