Drug interactions
Carbamazepine + Fedratinib
Severity: Major
Carbamazepine and Fedratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine is expected to substantially reduce fedratinib exposure, which could compromise control of myelofibrosis. Fedratinib is a CYP3A4 substrate and the combination has not been formally studied with strong inducers.
What this interaction means in plain words
Carbamazepine and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Carbamazepine induces CYP3A4, increasing fedratinib metabolism.
What to do
Avoid the combination and use a non-inducing anticonvulsant if possible. If unavoidable, monitor spleen and symptom response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Chloramphenicol + Fedratinib Major
- Cimetidine + Fedratinib Major
Frequently asked questions
Can I take Carbamazepine with Fedratinib?
MediHelp rates the interaction as major. Carbamazepine and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is expected to substantially reduce fedratinib exposure, which could compromise control of myelofibrosis. Fedratinib is a CYP3A4 substrate and the combination has not been formally studied with strong inducers.
How serious is the interaction between Carbamazepine and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing anticonvulsant if possible. If unavoidable, monitor spleen and symptom response closely.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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