Drug interactions
Fedratinib + Thioridazine
Severity: Contraindicated
Fedratinib and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP2D6, the main enzyme metabolizing thioridazine, which can raise thioridazine concentrations. Because higher levels are linked to QT prolongation and serious arrhythmias, this is a significant concern. Thioridazine is contraindicated with CYP2D6 inhibitors in its labeling.
What this interaction means in plain words
Fedratinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fedratinib belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of thioridazine increases its plasma concentrations.
What to do
Avoid concurrent use; choose an antipsychotic with lower QT risk that is not dependent on CYP2D6. If it cannot be avoided, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Fedratinib
Frequently asked questions
Can I take Fedratinib with Thioridazine?
MediHelp rates the interaction as contraindicated. Fedratinib and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fedratinib inhibits CYP2D6, the main enzyme metabolizing thioridazine, which can raise thioridazine concentrations. Because higher levels are linked to QT prolongation and serious arrhythmias, this is a significant concern. Thioridazine is contraindicated with CYP2D6 inhibitors in its labeling.
How serious is the interaction between Fedratinib and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an antipsychotic with lower QT risk that is not dependent on CYP2D6. If it cannot be avoided, monitor ECG and electrolytes closely.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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