Drug interactions
Amobarbital + Fedratinib
Severity: Major
Amobarbital and Fedratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4, which amobarbital induces. Lower fedratinib exposure may reduce efficacy in myelofibrosis.
What this interaction means in plain words
Amobarbital and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
CYP3A4 induction by amobarbital is predicted to increase fedratinib clearance.
What to do
Avoid strong CYP3A4 inducers and choose an alternative to amobarbital. Monitor spleen and symptom response if combined.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
- Cimetidine + Fedratinib Major
Frequently asked questions
Can I take Amobarbital with Fedratinib?
MediHelp rates the interaction as major. Amobarbital and Fedratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fedratinib is metabolized by CYP3A4, which amobarbital induces. Lower fedratinib exposure may reduce efficacy in myelofibrosis.
How serious is the interaction between Amobarbital and Fedratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers and choose an alternative to amobarbital. Monitor spleen and symptom response if combined.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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