Drug interactions
Amlodipine-olmesartan + Finerenone
Severity: Moderate
Amlodipine-olmesartan and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may slightly raise finerenone exposure. Olmesartan also raises hyperkalemia risk when combined with finerenone, a mineralocorticoid antagonist.
What this interaction means in plain words
Amlodipine-olmesartan and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Finerenone belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by amlodipine raises finerenone levels, and additive potassium retention occurs with angiotensin receptor blockade.
What to do
Monitor serum potassium and renal function at initiation and after dose changes, adjusting finerenone as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Finerenone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may slightly raise finerenone exposure. Olmesartan also raises hyperkalemia risk when combined with finerenone, a mineralocorticoid antagonist.
How serious is the interaction between Amlodipine-olmesartan and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and after dose changes, adjusting finerenone as needed.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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