Drug interactions
Amlodipine-olmesartan + Pretomanid
Severity: Minor
Amlodipine-olmesartan and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro, and olmesartan is a substrate of this transporter. Olmesartan exposure could rise, but clinical data are lacking.
What this interaction means in plain words
Amlodipine-olmesartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible inhibition of OATP1B3-mediated hepatic uptake of olmesartan.
What to do
Monitor blood pressure and for hypotension or renal effects during pretomanid therapy. No dose change is routinely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Amlodipine-olmesartan with Pretomanid?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OATP1B3 in vitro, and olmesartan is a substrate of this transporter. Olmesartan exposure could rise, but clinical data are lacking.
How serious is the interaction between Amlodipine-olmesartan and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for hypotension or renal effects during pretomanid therapy. No dose change is routinely needed.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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