Drug interactions
Apalutamide + Pretomanid
Severity: Major
Apalutamide and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may markedly reduce pretomanid concentrations through enzyme induction. Reduced exposure may compromise the efficacy of antituberculosis regimens and risk treatment failure or resistance.
What this interaction means in plain words
Apalutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Pretomanid belongs to Anti Bacterial.
Why it happens
Apalutamide induces CYP3A4, increasing the oxidative metabolism of pretomanid.
What to do
Avoid concurrent use; choose an alternative to apalutamide where feasible. Monitor treatment response closely if the combination cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Apalutamide with Pretomanid?
MediHelp rates the interaction as major. Apalutamide and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may markedly reduce pretomanid concentrations through enzyme induction. Reduced exposure may compromise the efficacy of antituberculosis regimens and risk treatment failure or resistance.
How serious is the interaction between Apalutamide and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; choose an alternative to apalutamide where feasible. Monitor treatment response closely if the combination cannot be avoided.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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