Drug interactions
Amobarbital + Pretomanid
Severity: Major
Amobarbital and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce pretomanid exposure through CYP3A4 induction. Lower levels may compromise efficacy in drug-resistant tuberculosis regimens.
What this interaction means in plain words
Amobarbital and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Pretomanid belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 increases the metabolism of pretomanid.
What to do
Avoid the combination and use a non-inducing alternative to amobarbital. Monitor treatment response if it cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Amobarbital with Pretomanid?
MediHelp rates the interaction as major. Amobarbital and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may reduce pretomanid exposure through CYP3A4 induction. Lower levels may compromise efficacy in drug-resistant tuberculosis regimens.
How serious is the interaction between Amobarbital and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to amobarbital. Monitor treatment response if it cannot be avoided.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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