Drug interactions
Amiodarone + Pretomanid
Severity: Major
Amiodarone and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The pretomanid regimen is associated with hepatotoxicity and amiodarone can also injure the liver. Using them together may increase the risk of liver injury.
What this interaction means in plain words
Amiodarone and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity.
What to do
Avoid if possible; otherwise monitor liver enzymes closely and stop therapy if significant hepatic injury develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Amiodarone with Pretomanid?
MediHelp rates the interaction as major. Amiodarone and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid regimen is associated with hepatotoxicity and amiodarone can also injure the liver. Using them together may increase the risk of liver injury.
How serious is the interaction between Amiodarone and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor liver enzymes closely and stop therapy if significant hepatic injury develops.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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