Drug interactions
Amlodipine-olmesartan + Rucaparib
Severity: Minor
Amlodipine-olmesartan and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise amlodipine exposure. This could slightly increase vasodilatory effects such as hypotension or peripheral edema.
What this interaction means in plain words
Amlodipine-olmesartan and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, which reduces the metabolism of amlodipine.
What to do
Monitor blood pressure and edema when rucaparib is started. Reduce the amlodipine dose only if hypotension or edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Amlodipine-olmesartan with Rucaparib?
MediHelp rates the interaction as minor. Amlodipine-olmesartan and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may modestly raise amlodipine exposure. This could slightly increase vasodilatory effects such as hypotension or peripheral edema.
How serious is the interaction between Amlodipine-olmesartan and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema when rucaparib is started. Reduce the amlodipine dose only if hypotension or edema develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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