Drug interactions
Ergotamine + Rucaparib
Severity: Major
Ergotamine and Rucaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP3A inhibitor in vitro and may increase ergotamine exposure. Raised ergotamine levels carry a risk of ergotism and vasospasm.
What this interaction means in plain words
Ergotamine and Rucaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing ergotamine clearance.
What to do
Avoid concurrent use if possible and choose a non-ergot alternative. If unavoidable, monitor closely for ischemic symptoms and use the lowest ergotamine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
- Bosentan + Rucaparib Moderate
Frequently asked questions
Can I take Ergotamine with Rucaparib?
MediHelp rates the interaction as major. Ergotamine and Rucaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rucaparib is a moderate CYP3A inhibitor in vitro and may increase ergotamine exposure. Raised ergotamine levels carry a risk of ergotism and vasospasm.
How serious is the interaction between Ergotamine and Rucaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible and choose a non-ergot alternative. If unavoidable, monitor closely for ischemic symptoms and use the lowest ergotamine dose.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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