Drug interactions
Aripiprazole + Rucaparib
Severity: Moderate
Aripiprazole and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and CYP2D6 to a modest extent and may raise aripiprazole levels. The increase is likely small to moderate.
What this interaction means in plain words
Aripiprazole and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2D6 and CYP3A4, reducing aripiprazole metabolism.
What to do
Monitor for akathisia, sedation and orthostatic symptoms and reduce the aripiprazole dose if these occur. Reassess the dose when rucaparib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
- Bosentan + Rucaparib Moderate
Frequently asked questions
Can I take Aripiprazole with Rucaparib?
MediHelp rates the interaction as moderate. Aripiprazole and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP3A4 and CYP2D6 to a modest extent and may raise aripiprazole levels. The increase is likely small to moderate.
How serious is the interaction between Aripiprazole and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for akathisia, sedation and orthostatic symptoms and reduce the aripiprazole dose if these occur. Reassess the dose when rucaparib is stopped.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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