Drug interactions
Atorvastatin + Rucaparib
Severity: Moderate
Atorvastatin and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and may moderately raise atorvastatin concentrations. Muscle adverse effects may be more likely.
What this interaction means in plain words
Atorvastatin and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP3A4, reducing atorvastatin metabolism.
What to do
Monitor for myalgia and CK elevation and reduce the atorvastatin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Bosentan + Rucaparib Moderate
Frequently asked questions
Can I take Atorvastatin with Rucaparib?
MediHelp rates the interaction as moderate. Atorvastatin and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP3A4 and may moderately raise atorvastatin concentrations. Muscle adverse effects may be more likely.
How serious is the interaction between Atorvastatin and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and CK elevation and reduce the atorvastatin dose if symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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