Drug interactions
Cisapride + Rucaparib
Severity: Major
Cisapride and Rucaparib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak to moderate inhibitor of CYP3A4 and may raise cisapride levels. Because cisapride has a narrow margin related to QT prolongation and torsades de pointes, even modest increases matter.
What this interaction means in plain words
Cisapride and Rucaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated cisapride metabolism increases cisapride exposure.
What to do
Avoid the combination where possible and choose an alternative prokinetic. If unavoidable, monitor ECG and QTc and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Rucaparib
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
- Bosentan + Rucaparib Moderate
Frequently asked questions
Can I take Cisapride with Rucaparib?
MediHelp rates the interaction as major. Cisapride and Rucaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rucaparib is a weak to moderate inhibitor of CYP3A4 and may raise cisapride levels. Because cisapride has a narrow margin related to QT prolongation and torsades de pointes, even modest increases matter.
How serious is the interaction between Cisapride and Rucaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative prokinetic. If unavoidable, monitor ECG and QTc and correct potassium and magnesium.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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