Drug interactions
Amlodipine-olmesartan + Sotalol
Severity: Moderate
Amlodipine-olmesartan and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol adds to blood pressure lowering and bradycardia with amlodipine and olmesartan. Hypotension or electrolyte disturbances such as hyperkalemia or renal dysfunction may matter because sotalol is renally cleared and proarrhythmic.
What this interaction means in plain words
Amlodipine-olmesartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hemodynamic effects; ARB-related changes in renal function and potassium may influence sotalol accumulation and arrhythmia risk.
What to do
Monitor blood pressure, heart rate, ECG (QT), potassium and renal function. Reduce sotalol dose if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Sotalol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol adds to blood pressure lowering and bradycardia with amlodipine and olmesartan. Hypotension or electrolyte disturbances such as hyperkalemia or renal dysfunction may matter because sotalol is renally cleared and proarrhythmic.
How serious is the interaction between Amlodipine-olmesartan and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, ECG (QT), potassium and renal function. Reduce sotalol dose if renal function declines.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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