Drug interactions
Amlodipine-olmesartan + Temsirolimus
Severity: Moderate
Amlodipine-olmesartan and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
mTOR inhibitors such as temsirolimus have been associated with angioedema, and this risk may be higher with other agents that affect bradykinin pathways, including ARBs and possibly calcium channel blockers. Reactions are usually uncommon but can involve the airway.
What this interaction means in plain words
Amlodipine-olmesartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Temsirolimus belongs to Oncology.
Why it happens
Not fully established; mTOR inhibitor angioedema is thought to be potentiated by drugs altering bradykinin or vascular permeability.
What to do
Counsel patients to report swelling of the face, lips or tongue immediately and stop the offending agents if angioedema occurs. Monitor for angioedema during the first weeks of therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Temsirolimus?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. mTOR inhibitors such as temsirolimus have been associated with angioedema, and this risk may be higher with other agents that affect bradykinin pathways, including ARBs and possibly calcium channel blockers. Reactions are usually uncommon but can involve the airway.
How serious is the interaction between Amlodipine-olmesartan and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the face, lips or tongue immediately and stop the offending agents if angioedema occurs. Monitor for angioedema during the first weeks of therapy.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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