Drug interactions
Bcg vaccine live + Temsirolimus
Severity: Contraindicated
Bcg vaccine live and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
BCG is a live attenuated vaccine, and in a patient immunosuppressed by temsirolimus the organism may replicate unchecked and cause disseminated BCG infection. The vaccine response may also be inadequate.
What this interaction means in plain words
Bcg vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of live attenuated organisms and reduces the vaccine response.
What to do
Do not give BCG vaccine during temsirolimus therapy. Defer vaccination until immunosuppression has resolved, as advised in product labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
- Rubella vaccine + Temsirolimus Contraindicated
Frequently asked questions
Can I take Bcg vaccine live with Temsirolimus?
MediHelp rates the interaction as contraindicated. Bcg vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. BCG is a live attenuated vaccine, and in a patient immunosuppressed by temsirolimus the organism may replicate unchecked and cause disseminated BCG infection. The vaccine response may also be inadequate.
How serious is the interaction between Bcg vaccine live and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG vaccine during temsirolimus therapy. Defer vaccination until immunosuppression has resolved, as advised in product labeling.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Temsirolimus page.
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