Drug interactions
Measles vaccine + Temsirolimus
Severity: Contraindicated
Measles vaccine and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Measles vaccine contains live attenuated virus, which may replicate excessively and cause disseminated disease in patients immunosuppressed by temsirolimus. The vaccine response may also be impaired.
What this interaction means in plain words
Measles vaccine and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of live attenuated virus replication.
What to do
Do not give live measles vaccine during temsirolimus therapy. Vaccinate at least several weeks before starting treatment or after immune recovery, per local guidance.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
- Rubella vaccine + Temsirolimus Contraindicated
Frequently asked questions
Can I take Measles vaccine with Temsirolimus?
MediHelp rates the interaction as contraindicated. Measles vaccine and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Measles vaccine contains live attenuated virus, which may replicate excessively and cause disseminated disease in patients immunosuppressed by temsirolimus. The vaccine response may also be impaired.
How serious is the interaction between Measles vaccine and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live measles vaccine during temsirolimus therapy. Vaccinate at least several weeks before starting treatment or after immune recovery, per local guidance.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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