Drug interactions
Rotavirus oral vaccine live + Temsirolimus
Severity: Contraindicated
Rotavirus oral vaccine live and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live oral rotavirus vaccine may cause prolonged or severe vaccine-strain infection in an immunosuppressed patient on temsirolimus. Vaccine response may also be reduced.
What this interaction means in plain words
Rotavirus oral vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of live attenuated virus replication.
What to do
Avoid the live rotavirus vaccine during temsirolimus therapy. Defer until immune function recovers.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Rotavirus oral vaccine live and Temsirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rubella vaccine + Temsirolimus Contraindicated
Frequently asked questions
Can I take Rotavirus oral vaccine live with Temsirolimus?
MediHelp rates the interaction as contraindicated. Rotavirus oral vaccine live and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live oral rotavirus vaccine may cause prolonged or severe vaccine-strain infection in an immunosuppressed patient on temsirolimus. Vaccine response may also be reduced.
How serious is the interaction between Rotavirus oral vaccine live and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live rotavirus vaccine during temsirolimus therapy. Defer until immune function recovers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
