Drug interactions
Influenza virus vaccine quadrivalent intranasal + Temsirolimus
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Temsirolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which could replicate and cause illness in a patient immunosuppressed by temsirolimus. The vaccine response may also be inadequate.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
mTOR-mediated immunosuppression impairs control of live attenuated virus replication.
What to do
Do not use the live intranasal vaccine during temsirolimus therapy. Give an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
- Rubella vaccine + Temsirolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Temsirolimus?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Temsirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which could replicate and cause illness in a patient immunosuppressed by temsirolimus. The vaccine response may also be inadequate.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Temsirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine during temsirolimus therapy. Give an inactivated injectable influenza vaccine instead.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Temsirolimus page.
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