Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Asenapine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Asenapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With this three-drug antihypertensive, the blood pressure lowering is additive, increasing the risk of dizziness, syncope and falls.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Asenapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from asenapine alpha-1 antagonism and the antihypertensive drugs.
What to do
Monitor orthostatic blood pressure when asenapine is started or the dose increased. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Asenapine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Asenapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine blocks alpha-1 adrenergic receptors and can cause orthostatic hypotension. With this three-drug antihypertensive, the blood pressure lowering is additive, increasing the risk of dizziness, syncope and falls.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Asenapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when asenapine is started or the dose increased. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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