Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Brimonidine
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Brimonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine is an alpha-2 agonist that can be absorbed systemically and occasionally cause hypotension and bradycardia. The effect is usually small, but it may add to the antihypertensive effect of this combination.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Brimonidine belongs to Miscellaneous.
Why it happens
Central alpha-2 agonism may add to the blood pressure lowering of the antihypertensives.
What to do
No routine change is needed; monitor blood pressure if dizziness or fatigue occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Brimonidine?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine is an alpha-2 agonist that can be absorbed systemically and occasionally cause hypotension and bradycardia. The effect is usually small, but it may add to the antihypertensive effect of this combination.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Brimonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor blood pressure if dizziness or fatigue occurs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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