Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Chlorpropamide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and so reduce the effect of chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide can cause through enhanced ADH effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Thiazide-induced impaired insulin secretion and insulin resistance oppose sulfonylurea action; additive hyponatremia risk.
What to do
Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Chlorpropamide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and so reduce the effect of chlorpropamide. Thiazides may also contribute to hyponatremia, which chlorpropamide can cause through enhanced ADH effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium, and adjust the antidiabetic regimen as needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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