Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Chlorthalidone
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone duplicates the thiazide-type diuretic component and increases the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion. Blood pressure lowering is additive and may cause hypotension or renal function decline.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Why it happens
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive diuresis and electrolyte loss.
What to do
Avoid duplicate thiazide-type therapy where possible. If combined, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Chlorthalidone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone duplicates the thiazide-type diuretic component and increases the risk of hypokalemia, hyponatremia, hypomagnesemia, hyperuricemia and volume depletion. Blood pressure lowering is additive and may cause hypotension or renal function decline.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy where possible. If combined, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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